What are the key considerations in choosing excipients for topical formulations?

In this whitepaper, we review the effect of excipient choice on the process of manufacturing topical products. The effect of the following excipient types will be discussed: surface active agents, preservatives, polymer choice and skin penetration enhancers.

Considerations include the following:

  • Understanding equipment differences and their potential impact on the process

  • Extensive sampling throughout each unit operation to understand process parameters and process efficiency

  • Performing key tests on the spot to understand required duration for individual process steps

  • Designing the testing plan to balance testing resource with knowledge benefit

  • Process stretching studies on key process parameters